This study aimed to determine the role of selected polymorphisms in ACE (rs4646994), ACE2 (rs2285666), and AGTR2 (rs1403543) in the presence of COVID-19, its severity, and their association with the presence of the COVID-19 retinopathy using fundus photography in patients without known comorbidities and compare it with healthy, age-matched controls. This evidence concerns the gene ACE2 and COVID-19.