Another study showed that, in esophageal squamous cell carcinomas, S100A2 expression is significantly higher in well-differentiated tumors and lower lymph node metastasis samples in vivo [86], while S100A2-overexpressing tumor cells exhibit a high frequency of lymph node and distant metastases in esophageal squamous cell carcinoma in vivo [87]. The gene discussed is S100A2; the disease is esophageal squamous cell carcinoma.