In consideration, hypoalphalipoproteinemia is a common dyslipidemia found in both T2DM and premature CAD patients, and we recently reported that the rs17574 DPP4 polymorphism was associated with a low risk of hypoalphalipoproteinemia [25]; this study aimed to investigate the association of pCAD with the rs17574 DPP4 polymorphism and with the protein concentration in diabetic patients belonging to the GEA Mexican study. The gene discussed is DPP4; the disease is apolipoprotein A-I deficiency.