Regarding associations between specific BAP1 mutations and a peculiar disease phenotype, in 2018 a comprehensive study [7] collating data from 181 BAP1-TPDS families showed that among patients who developed mesothelioma, melanoma, and other tumors, those carrying a null BAP1 mutation had an earlier age of onset than patients with missense mutations. This evidence concerns the gene BAP1 and mesothelioma.