Upon somatic NGS analysis of both the proband’s (II-3) and her brother’s (II-2) tumor samples, we identified a second variant: p.Arg1076His in MSH6 (48% VAF in the proband’s mesothelioma and RCC; 25% VAF in her brother’s mesothelioma) (Table 2). This evidence concerns the gene MSH6 and mesothelioma.