In addition, the median ESR, CRP, swollen joint count (SJC), total joint count, and frequency of RF positivity and anti-CCP antibody positivity in patients with clinical RA, DMARDs RA, and classified RA were significantly higher than those with non-clinical RA, non-DMARD RA, and non-classified RA, respectively. The gene discussed is ESR1; the disease is rheumatoid arthritis.