Therefore, we have chosen a group of several novel epigenetic biomarkers (RAD51B, GFRA3, AKR7A3, HOXA11, TUSC3, FLI1, SEZ6L, GLDC, NDRG) and validated in the set of tissue samples of primary gastric adenocarcinoma, both diffuse and intestinal histological type. The gene discussed is HOXA11; the disease is gastric adenocarcinoma.