In a univariate Cox analysis, we identified tumor size (pT) (HR = 5.95, 95% CI 1.8–19.13), lymph nodes metastasis (HR = 3.59, 95% CI 1.6–7.99), invasion into blood vessels (HR = 2.65, 95%PI 1.35–5.2), invasion into lymph vessels (HR = 3.8, 95% CI 1.37–10.6) and HOXA11 promoter methylation (HR = 2.48, 95%PI 1.24–5) as significantly associated with shorter survival. This evidence concerns the gene HOXA11 and neoplasm.