Therefore, although the correlations and interactions of sex hormones with MMP-11 expression have remained unclear to date, it can be proposed that it is the AR presence induced by higher levels of MMP-11 expression which result from MMP-11 rs131451 “CC + CT” polymorphisms, but also the direct interaction of testosterone and MMP-11, which is responsible for the discrepancy of sex specificity and poor prognosis in prostate cancer [61] and CRC [30,31] (Table 4) (Figure 2). This evidence concerns the gene MMP11 and Familial prostate cancer.