In 369 of a total 479 CRC patients, a significant association was found in those individuals who carried the MMP-11 rs738792 “TC + CC” genotypic variants, with a higher risk of perineural invasion of colon cancer patients after controlling for stages, tumor T status, lymph node status, metastasis, lymphovascular invasion, and cell differentiation (p = 0.025) (Table 3). This evidence concerns the gene MMP11 and malignant colon neoplasm.