AR and cancer: Moreover, in the aspect of androgen receptor (AR), it was suggested that the expression of MMP-2 and MMP-9 was associated with the presence of AR in epithelial ovarian tumors [60], and the expressions of the MMP-11 and AR were significantly higher in cancer-associated fibroblasts (CAFs) from castration-resistant prostate tumors (CRPC) [61], suggesting a possible mechanism: that the higher MMP-11 expression resulting from MMP-11 rs131451 polymorphisms might be associated with the induction of AR presence in CRC (Table 4) (Figure 1 and Figure 2).