Of note, the MMP-11 rs131451 “TC + CC” genotype was further associated with greater tumor T status (p = 0.028) and perineural invasion (p = 0.040) in male CRC patients (Table 4), thereby providing a possible more detailed mechanism to explain the reason why the sex discrepancy of MMP-11 expression in CRC exists, and result in CRC disease development and prognosis with sex differences [31]. This evidence concerns the gene MMP11 and colorectal carcinoma.