The MMP-11 SNPs were found to be associated with increased risk of cancer progression and development, metastasis, recurrence, or poor prognosis in many cancers including oral squamous cell carcinoma (OSCC) [34], hepatocellular carcinoma (HCC) [35,36], prostate cancer [37], and urothelial cell carcinoma (UCC) [38]. This evidence concerns the gene MMP11 and Familial prostate cancer.