We further analyzed the correlations between the MMP-11 SNPs and clinical status of CRC, and we found that in 369 of a total 479 CRC patients, individuals who carried the MMP-11 rs738792 “TC + CC” polymorphic variants were associated with higher risk of perineural invasion in colon cancer patients after controlling for clinical parameters (p = 0.025) (Table 3). This evidence concerns the gene MMP11 and malignant colon neoplasm.