Moreover, after we analyzed the MMP-11 polymorphisms of the clinical status in CRC patients with different genders, we found that the male CRC patients who carried the MMP-11 rs131451 “TC + CC” genotypic variants were correlated with greater tumor T status (p = 0.028) and perineural invasion (p = 0.040) (Table 4). Here, MMP11 is linked to neoplasm.