In contrast, in the aspect of CRC prognostic biomarkers, it was suggested that there are clear sex differences in CRC characteristics, and sex-specific CRC prognostic biomarkers including ESM1, GUCA2A, and VWA2 for males and CLDN1 and FUT1 for female CRC patients were proposed [53]. This evidence concerns the gene GUCA2A and colorectal carcinoma.