In conclusion, our results have demonstrated that despite the fact that MMP-11 SNPs were not associated with CRC susceptibility, CRC patients who carried the MMP-11 rs738792 “TC + CC” polymorphic variants were associated with higher risk of perineural invasion of the colon, and the male CRC patients who carried the MMP-11 rs131451 “TC + CC” genotypic variants were associated with greater tumor T status and perineural invasion. Here, MMP11 is linked to colorectal carcinoma.