In mice, knockdown of miR-145 and miR-146a together or enforced expression of TRAF6 in mouse HSPCs phenocopies several clinical features of del(5q) MDS (thrombocytosis, mild neutropenia and megakaryocytic dysplasia) and can lead to marrow failure or AML [61]. The gene discussed is TRAF6; the disease is myelodysplastic syndrome.