IGKV1D-22 and Shwachman-Diamond syndrome: Furthermore, in a murine model of Shwachman–Diamond syndrome (SDS), a rare congenital disorder notably characterized by ineffective blood cell production, MSCs were shown to induce, through an abnormal p53-mediated secretion of S100A8/A9, mitochondrial hyperpolarization and an increase in ROS and DNA damage response.