Furthermore, in a murine model of Shwachman–Diamond syndrome (SDS), a rare congenital disorder notably characterized by ineffective blood cell production, MSCs were shown to induce, through an abnormal p53-mediated secretion of S100A8/A9, mitochondrial hyperpolarization and an increase in ROS and DNA damage response. The gene discussed is TP53; the disease is Shwachman-Diamond syndrome.