The vast majority of BCC have a fibro-myxoid stroma [6], which is composed of glycosaminoglycan-based ground substance with a complex network of collagen, elastin and fibronectin [27], along with inflammatory cells and fibroblasts that interact with tumor cells via growth factors or extracellular matrix proteins secretion, thus influencing tumor growth and progression, as well as angiogenesis or metastasis [28,29,30]. Here, FN1 is linked to neoplasm.