More recent studies reflected on the effects of MMPs, such as MMP-2 and MMP-9, and stated that extracellular matrix remodeling plays a significant part alongside a decreased expression of adhesion molecules [65], although other metalloproteinases, such as stromelysin-3, were believed to be involved in tumor invasion via degradation of the matrix of the stroma [66]. The gene discussed is MMP2; the disease is neoplasm.