For example, in a number of murine models of CH or MDS, such as the TET2−/− and 5q− MDS models, we observe an increase in alarmins (S100A8, S100A9), with the activation of the inflammasome NLRP3, which directs the generation of IL1β, S100A9 and ROS, creating a proinflammatory environment [49,50]. The gene discussed is S100A8; the disease is myelodysplastic syndrome.