The cumulative survival rates of HCC patients with ≥5 cm sized tumor and high PrPC expression, <5 cm sized tumor and high PrPC expression, ≥5 cm sized tumor and low PrPC expression, and <5 cm sized tumor and high PrPC expression had statistically significant difference (57.1%, 89.5%, 92.9%, and 100%, respectively; p < 0.001). Here, PRNP is linked to hepatocellular carcinoma.