CEACAM5 and neoplasm: Interestingly, some authors proposed to combine imaging and biochemical data to create a more accurate and less operator-dependent preoperative system, showing how tumor diameter and preoperative CEA values were independent predictors of a T stage ≥ to pT2, and building a regression formula with an area under the receiver operating characteristics (ROC) curve of the obtained pT2 predictive score as high as 0.873 [20].