A subsequent landmark study analyzed four large case-control studies (in total 4726 participants with coronary heart disease and 3529 controls) and clearly established the association between CHIP and coronary heart disease with a 1.9 times greater risk for CHIP carriers after adjustment for the traditional cardiovascular risk factors age, sex, type 2 diabetes, and smoking [42]. The gene discussed is STUB1; the disease is coronary artery disorder.