Importantly, the data on the association of CHIP and cardiovascular disease do not only rely on association studies but also build on multiple lines of evidence from in vitro and in vivo models showing a mechanistic link between somatic mutations in CHIP, proinflammatory state of myeloid cells and inflammation-induced effects on atherosclerosis and cardiac remodeling [42,64,65,66,67]. The gene discussed is STUB1; the disease is atherosclerosis.