Moreover, characteristic molecular differences can be found between pediatric and adult PLMM: in fact, as we reported previously and according to a well-developed murine model by Pendersen et al., the mutated NRAS (NRASQ61K) is strictly associated with childhood melanoma of the CNS, while GNAQ and GNA11 mutations drive adult melanoma [1,2]. The gene discussed is GNAQ; the disease is melanoma.