Another study found that over-expression of miR-146a, or knockdown of cyclin J (CCNJ), produces the same effect: improved sensitivity to cisplatin mediated through inhibition of cell cycle, cell viability, and motility, and promotion of apoptosis in cisplatin-resistant NSCLC cell lines (A549, SPC-A1). Here, CCNJ is linked to non-small cell lung carcinoma.