Sustaining the inflammasome hypothesis of depression, Zhang et al. [86] reported that the NLR family pyrin domain containing 3 (NLRP3) knock-out mice exhibits a significantly greater locomotor activity and increased Lachnospiraceae, Ruminococcaceae, and Prevotellaceae abundance to the detriment of Bacteroides. This evidence concerns the gene NLRP3 and major depressive disorder.