-Social deficits and increased anxiety;-Differential regulation of Arc, Btg2, Fosb, Egr4, or Klf2 in a sex-dependent manner;-Lachnospiraceae ↓, Porphyromonadaceae ↓, Mucispirillum ↓, Firmicutes ↑, Bacteroides ↑, Lactobacillus ↑↓, Alloprevotella ↑;. This evidence concerns the gene ARC and Anxiety.