NGS analysis of her GIST lesion revealed a quadruple wild-type tumor (no mutations in c-KIT, PDGFRA, SDH, RAS-P [RAS, BRAF, NF-1]) with a FGFR3 p.G145S mutation/variant which is of a germline rather than somatic variation. Here, SDHB is linked to gastrointestinal stromal tumor.