On the other hand, both the C/T and C/C genotypes for DHFR gene rs10072026 were significantly associated with a positive response to MTX treatment under dominant comparison, with a 0.05-fold change for a negative response to MTX (OR = 0.05, 95% CI = 0.02−0.17, p-value = 0.0001), indicating their good prognostic significance for MTX treatment in RA patients (Table 5). The gene discussed is DHFR; the disease is rheumatoid arthritis.