IFNG and Graves disease: Graves’ disease is known as a Th1-mediated disease, and IFN-γ is crucial in promoting thyroid antigen presentation via the HLA class II and, ultimately, the synthesis of class 1 IgG, which stimulates the TSH receptor; importantly, a study showed that the immune response to the BNT162b2 vaccine was from a Th1 type with IFN-γ production.