ZNF582m, with the product name of ZNF582 DNA Detection Kit (iStat Biomedical, New Taipei City, Taiwan), is a Conformité Européene in vitro diagnostic (CE-IVD), which has been used as an adjunctive tool assisting VOE for oral cancer by clinicians to facilitate decision making on whether a histopathological examination should be performed immediately [8,25,29,30]. Here, ZNF582 is linked to lip and oral cavity carcinoma.