The univariate logistic regression analysis showed that respiratory rate (OR 1.149; [95% CI, 1.057–1.248], p = 0.001), bilirubin (OR 2.532; [95% CI,—1.099–5.836], p = 0.029), LDH (OR 1.001; [95% CI, 1.000–1.003], p = 0.018), CRP (OR 1.010; [95% CI, 1.002–1.017], p = 0.012), the need for invasive MV (OR 7.667; [95% CI, 2.118–27.755], p = 0.002), the presence of pulmonary consolidation (OR 0.082; [95% CI, 0.029–0.235], p < 0.001), and higher TSS (OR 2.082; [95% CI1.579–2.745], p < 0.001) were the main risk factors for mortality among COVID-19 patients with ARI/CKD, as shown in Table 3. This evidence concerns the gene CRP and COVID-19.