They recommended that AL CA can be diagnosed if an extracardiac biopsy proves the presence of systemic amyloidosis, CMR and echocardiography are not diagnostic for CA, but significant age-adjusted elevation in NTproBNP/BNP or troponin level is present, with the exclusion of all other causes for these biomarker changes. The gene discussed is NPPB; the disease is axial length measurement.