MAPT and supranuclear palsy, progressive, 1: Although NFL in CSF and blood can differentiate between PD and APD, they cannot be used as a tool to differentiate between APD with synuclein depositions (MSA), and APD related to the depositions of pathologically changed protein tau (tauopathies) as progressive supranuclear palsy (PSP) and corticobasal degeneration (CBD).