Therefore, dysregulation in the balance between IL-18 and IL-18BP results in various disease conditions, which are mainly associated with immunity, an immune response against non-self-antibodies (pathogens), such as viruses, an immune reaction against self-antibodies (autoimmune reactions), and immunity toward cancers [28,29,30,31,32,33,34,35,36,37,38]. The gene discussed is IL18; the disease is cancer.