Expression of LOX is also associated with increased aortic stiffness [4], whereas low LOX plasma concentrations or low extracellular activity of LOX are linked to aortic rupture and aortic aneurysm, specifically in the context of an activated renin–angiotensin–aldosterone system (RAAS) [5,6,7]. The gene discussed is LOX; the disease is aortic aneurysm.