Interestingly, Wang et al. 2018 described an early exhaustion of IL13Rα2+-targeting CD8+ CAR-T cells upon stimulation with IL13Rα2+ GBM cells and in an orthotopic GBM model in vivo; compared to a persistent activation of CD4+ CAR-T cells [96]. This evidence concerns the gene IL13RA2 and glioblastoma.