Whereas multiple infusions of 10 × 106 IL13Rα2-directed CAR-T cells were administered into the resection cavity in a patient with recurrent GBM, i.c.v. infusion at a late stage of multifocal tumor recurrence caused a regression of intracranial and spinal manifestations with a persistent clinical response for 7.5 months [46]. Here, IL13RA2 is linked to glioblastoma.