In the PPI analysis, we identified the top 10 therapeutic targets of BBR for obesity treatment (in the order of highest degree: SRC, CDC42, RAC1, PIK3CB, JAK2, MAPK14, CDK4, PTPN1, PIK3CG, and ROCK1). This evidence concerns the gene PTPN1 and obesity due to melanocortin 4 receptor deficiency.