Only a few studies exist on GPR119, free fatty acid receptor 1 (FFAR1/GPR40) and 4 (FFAR4/GPR120), and the bile acid receptor GPBAR1 (TGR5) as a developer of insulin resistance and β-cell dysfunction [22], receiving particular attention as targets for therapeutic interventions in diabetic patients [22]. This evidence concerns the gene FFAR4 and Insulin resistance.