DSCAM-AS1 in EC tissue was considerably associated with expression both of PRL gene coding for prolactin, a highly potent driver of endometrial cancer development and progression, and with PRLH gene, coding for prolactin releasing hormone, and the results of GSEA showed an overlap of the positively correlated genes with a set of common cancer genes; thus, it is tempting to speculate that these results support the oncogenic role of this lncRNA in this cancer entity. This evidence concerns the gene PRL and cancer.