Sciellin (SCEL) gene, being downregulated about 6-fold after knockdown of DSCAM-AS1, has been recently reported to promote invasion and metastasis of colon cancer (CRC) cells, to increase WNT signaling by activating β-catenin and its downstream target c-myc, and to activate mesenchymal-to-epithelial transition (MET) through a SCEL-β-catenin-E-cadherin axis [68]. This evidence concerns the gene SCEL and malignant colon neoplasm.