The observed overexpression of DSCAM-AS1 in endometrial cancer, its association with tumor-promoting genes in endometrial cancer tissue and the effects of DSCAM-AS1 silencing, resulting in growth inhibition of HEC-1B cells via downregulation of proliferation activators and a broad anti-tumoral transcriptome response, substantiate an oncogenic role of DSCAM-AS1 in endometrial cancer. The gene discussed is DSCAM-AS1; the disease is endometrial cancer.