ACE and hydrops fetalis: Therefore, optimizing pharmacological treatments in HF by up-titrating doses of all HF drugs (i.e., angiotensin converting enzyme inhibitors (ACEis), angiotensin-II receptor blockers (ARBs), mineralcorticoid receptor antagonists (MRAs), angiotensin receptor-neprilysin inhibitors (ARNIs), beta-blockers, and sodium-glucose cotransporter-2 inhibitors (SGLT2is)) has the main goal to be achieved by clinicians [3].