Meanwhile, deleting several other genes such as p53, Kirstein rat sarcoma viral oncogene homolog (KRAS), and phosphatase and tensin homolog (PTEN) have also been reported to contribute CRC development [7], although not all of these genetic alterations are similar to Apc mutation, which can induce spontaneous colon tumorigenesis. This evidence concerns the gene PTEN and colorectal carcinoma.