The urine oxidative stress biomarkers (including elevated 8-OHdG and 8-isoprostane levels) and inflammatory cytokines profiles (including elevated MCP-1, RANTES, CXCL10, and Eotaxin levels) of the IC/BPS patients were distinct from that of the controls. This evidence concerns the gene CCL2 and Bartsocas-Papas syndrome 1.