SLC22A12 and hypertensive disorder: Tabara et al. found that the URAT1 W258X allele, which is the most common mutant URAT1 allele in Japan, was independently associated with a low estimated glomerular filtration rate (eGFR) after multiple adjustments for clinical factors, including hypertension, SUA concentration, and body mass index (BMI), in two cohorts recruited from different Japanese cities [18].