With regard to LP genes, regardless of their PBC disease stage, the B-cell receptor signalling pathway was the most enriched (p < 3.33 × 10−16, FDR < 1.25 × 10−14), enriched by 16 genes (AKT1, mitogen-activated proteins, and inhibitors of nuclear factor-kappa B-kinase subunits), followed by other interesting pathways, such as the neurotrophin signalling pathway (p < 3.33 × 10−16, FDR < 1.25 × 10−14), enriched by 19 genes (CALM2/3, mitogen-activated proteins, TP53, RELA, and others). Here, AKT1 is linked to primary biliary cholangitis.