VHL and breast cancer: Interestingly, LP genes propagated from initial PBC early stages seed genes were found to be enriched for ubiquitin-mediated proteolysis pathways (p = 6.84 × 10−14, FDR = 3.07 × 10−11) by 17 genes (BIRC3, genes from the cullin family, FBX11, FBXW7, VHL, and WWP2 genes) and integrated breast cancer pathway (p = 3.88 × 10−14, FDR = 2.09 × 10−11) by 18 genes (AR, BRCA1, MYC, KRAS, EGFR, and USP15, among others).