Naringin (10 or 20 μM) suppressed proliferation and invasion in human osteosarcoma MG63 cells by inhibiting zinc finger E-box binding homeobox 1, a transcriptional repressor of epithelial differentiation involved in tumor metastasis, resulting in downregulation of cyclin D1 and matrix metalloproteinase 2 (MMP-2) [94]. The gene discussed is MMP2; the disease is neoplasm.