Multiple flavanones regulate the autophagy of tumor cells by targeting the mTOR signal pathway or stimulate autophagy by targeting apoptosis-related proteins or HMGB1(HMGB1 is secreted by immune cells, such macrophages, monocytes and dendritic cells) to regulate the interaction between Bcl-2 and Beclin-1 [77]. Here, HMGB1 is linked to neoplasm.