VCAM1 and bone neoplasm: At noncytotoxic concentrations (3–30 μM), naringin downregulated vascular cell adhesion molecule-1 (VCAM-1) by increasing miR-126, thus suppressing the migration and invasion of the cells in chondrosarcoma, a primary malignant bone cancer that is highly invasive and tends to form distant metastases, especially in the lungs [95].