EGFR and cancer: Furthermore, flavonoids act as pro-oxidants and may suppress proliferation of cancer cells through the inhibition of epidermal growth factor receptor and mitogen-activated protein kinase (EGFR/MAPK), as well as phosphatidylinositide 3-kinase (PI3K), protein kinase B (AKT) and nuclear factor-kappa-light-chain-enhancer of activated B cells (NF-κB).