The generated EC ORT and SC models can be used for the preclinical testing of novel drug delivery approaches that target CXCR4+ EC cells for the treatment of high risk or advanced CXCR4+ EC, as well as to study the mechanisms of tumor growth and metastatic dissemination that are dependent on CXCR4 overexpression signaling. Here, CXCR4 is linked to neoplasm.