Moreover, in the SLE patients, the addition of 1 μM of 2-AG induced a decrease in IFN-ɣ expression compared to untreated (p = 0.0005), whilst HD treatment with increasing doses of 2-AG did not provide any difference in IFN-ɣ expression from PBMCs compared to the untreated condition (Figure 1C,D). This evidence concerns the gene IFNA1 and systemic lupus erythematosus.