IFNA1 and systemic lupus erythematosus: Our results show that treatment with 1 μM of 2-AG+AM630 significantly increased IFN-ɣ expression in Th1 lymphocytes of SLE patients compared to Th1 lymphocytes treated only with 2-AG (p = 0.03, Figure 3B), confirming the involvement of CB2 antagonist.