Furthermore, IFN-ɣ +874 T/A polymorphism is associated with an increased risk of SLE development in the Chinese Han population [44], and IFN-related genes play a pivotal role in SLE pathogenesis, especially IFN-ɣ and IFN-ɣ inducible GBP1 gene in the early stages of the disease [45]. This evidence concerns the gene GBP1 and systemic lupus erythematosus.