Biological mechanisms implied in the prostate tumor microenvironment characterization represented by the cell cycle, apoptosis, adhesion glycoproteins, T lymphocytes infiltrations, Ki-67, and intratumoral CD 34 biomarkers provide efficient means of measurement by flow cytometry and IHC techniques for PCa and BPH tissue samples and should be explored in the future not only for diagnostics but also for therapeutic purposes. Here, MKI67 is linked to prostate neoplasm.