CD4 and colorectal carcinoma: It also limits the activity of CD4+ and CD8+ T cells, repressing the differentiation of regulatory T cells and promoting the differentiation of Th17 cells from naive CD4+ lymphocytes, contributing to the overexpression of pro-cancerogenic cytokines in CRC, such as IL-17A, IL17F, IL-21, and IL-22, as well as their interactions with non-immune cells [40,93,94].