Eleven genes (i.e., DLD, IDH2, CS, DLST, MDH2, ACO2, IDH3G, OGDH, PCK2, ACO1 and PC) were increased, while nine genes (i.e., IDH3A, MDH1, MDH1B, GOT2, PCK1, GLUD1, GOT1, IDH1 and TAT) were reduced in the NASH state (Figure 7B). The gene discussed is MDH1; the disease is metabolic dysfunction-associated steatohepatitis.