APOA2 and congestive heart failure: Serum levels of HDL-apoA-II, HDL2-apoA-II, and HDL3-apoA-II were significantly lower in patients with sign(s) of venous volume overload (enlarged liver, peripheral edema, ascites, or jugular venous distension) than in those without, as well as in patients who developed AHF on the top of CHF compared with those developing new-onset AHF (Table 4).