To assess it and to further clarify the molecular mechanisms possibly involved, we pointed our attention on MCL-1: the anti-apoptotic member of the B-cell lymphoma 2 family (BCL-2), whose protein levels correlate with malignancy, and drug resistance in many tumors, including pancreatic cancers [23,24,25,26,27,28]. This evidence concerns the gene BCL2 and familial pancreatic carcinoma.