The role of neutrophils in thrombus formation is further confirmed by numerous proof: their depletion and their inability of producing NETs due to deficiency in peptidyl-arginine deiminase 4 (PAD 4), and NET degradation by the administration of DNase or deficiency in P-selectin prevents DVT in murine models [35,67,93,94]. Here, SELP is linked to deep vein thrombosis.