TF and Sepsis: On the other hand, in systemic inflammatory syndromes such as sepsis; chemical or physical vascular damage sustained by infectious pathogens; inflammatory cytokines (TNFα, IL-1 and IL-6); reactive oxygen species (ROS) or other injurious agents, can interrupt the integrity of the endothelial barrier with the exposure of collagen and tissue factor (TF) to the bloodstream, with TF rapid upregulation on perivascular cells and monocytes [54].