However, when the local damage becomes systemic and sustained, as in sepsis, there is an upregulation of procoagulant mechanisms with a shift towards this state [36,75], and the vWF and TF pathways tend to converge, combining venous micro- and macrothrombosis [19,20], with a prominent role of TF in the development of VTE [48,76]. Here, TF is linked to Sepsis.