IL6 and hypertensive disorder: Namely, there was a two-fold upregulation of IL6 (Figure 5E, note different scale of y-axis), and significant upregulation of the IL6R (Figure 5F), underscoring the importance of intact β-adrenergic signaling for preventing IL6R overactivation under increased workload, which presents itself as high-frequency beating or increased afterload due to hypertension.