Indeed, (i) in patients with DN, the inhibition of RAS with captopril, an angiotensin-converting enzyme inhibitor, reduced the risk of DN patients reaching end-stage renal disease by half [9]; (ii) proteinuria is a recognized marker of kidney injury and is used to monitor the prognosis and the response to treatment of injured kidneys [10]; and angiotensin II type I receptor (AT1R) inhibitors decreased proteinuria in patients with DN [11]. This evidence concerns the gene AGTR1 and chronic kidney disease.