To draw a link between the pathogenesis of T2DM-induced renal vascular abnormalities and kidney injury including fibrosis, we determined the correlation between AT1R or the collagen deposition score (kidney fibrosis) and the tissue and blood levels of ET-1, eNOS, iNOS, AGEs, MAP, urea and glucose. The gene discussed is EDN1; the disease is type 2 diabetes mellitus.