The exposure of MM1S and H929 cells to emodin (30 μM), carfilzomib (5 nM), or a combination of both inhibited BCL2 mRNA expression (p < 0.001), which was accompanied by significant caspase-3 activation and PARP cleavage after 24 h treatment, indicating that MM cells are undergoing apoptosis (Figure 5). Here, CASP3 is linked to Miyoshi myopathy.