CD40LG and premenstrual tension: Looking at the intrathecally synthesized IgA and M levels given as local concentrations (IgALoc, IgMLoc) shows that no significant differences between early and late onset RMS and early and late PMS were found for local IgM concentrations (p = 0.0845) but that PMS patients have higher local IgA concentrations in the CSF than RMS patients, independent of the age of onset (overall p = 0.0123) (Figure 3B,C).