Meanwhile, the results illustrated that GDF15 modulates epithelial-mesenchymal transition (EMT) markers NDRG1, and maspin to suppress the cellular proliferation, invasion, and growth of bladder carcinoma cells in vitro and in vivo, and is defined as an antitumor marker of bladder cancer [6,14]. The gene discussed is NDRG1; the disease is urinary bladder carcinoma.