DUX4 and facioscapulohumeral muscular dystrophy: With remarkable progress over the last two decades in the understanding of FSHD pathogenesis and the contribution of abhorrent DUX4 expression, numerous DUX4-silencing strategies have been extensively developed [14,15,16,17,18,19,20,21,22,23,24,25,26,27,28,29,30,31,32,33].