We demonstrate that CCL4 promotes Angpt2 expression in OSCC by activating signal transducer and activator of transcription 3 (STAT3) and mitogen-activated protein kinase kinase (MEK), signal-regulated kinase 1/2 (ERK) signaling, which subsequently enhances Angpt2-induced tumor angiogenesis. The gene discussed is CCL4; the disease is neoplasm.