Much evidence points to the involvement of Angpt2 in the pathogenesis of various cancers, including OSCC, where evidence suggests that Angpt2 overexpression stimulates angiogenesis and increases metastasis in a mouse model of OSCC, potentially in part by inducing abnormal epithelial-mesenchymal transition (EMT)-induced angiogenesis [14]. This evidence concerns the gene ANGPT2 and cancer.