Studies on tumor angiogenesis and metastasis have been able to highlight the importance of Angpt2 in different cancers; for instance, Angpt2 overexpression promotes the invasive abilities of cervical cancer cells, while the blockade of Angpt2 significantly decreases the expression of vimentin (a marker for EMT) and microvessel density in mice bearing cervical tumors [36]. This evidence concerns the gene VIM and uterine cervix neoplasm.