ANGPT2 and hepatocellular carcinoma: The significance of Angpt2 in metastasis is reflected by evidence showing that the inhibition of Angpt2 significantly disrupts a prevalent vascular pattern in hepatocellular carcinoma, i.e., Angpt2 is essential for the formation of vessels that encapsulate tumor clusters (VETC) and facilitate venous invasion of tumor cells; inhibiting VETC formation effectively suppresses VETC-dependent intrahepatic metastasis [12].